Drug interactions
Choline magnesium trisalicylate + Oxacillin
Severity: Minor
Choline magnesium trisalicylate and Oxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates compete with penicillins for renal tubular secretion and for plasma protein binding, which can modestly raise and prolong oxacillin levels. Trisalicylate is given at anti-inflammatory doses, so the effect may be more noticeable than with low-dose aspirin, particularly in renal impairment.
What this interaction means in plain words
Choline magnesium trisalicylate and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competes with oxacillin for renal tubular secretion and for albumin binding.
What to do
No routine adjustment is needed at usual doses. Monitor for oxacillin adverse effects in patients with renal impairment or receiving high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Frequently asked questions
Can I take Choline magnesium trisalicylate with Oxacillin?
MediHelp rates the interaction as minor. Choline magnesium trisalicylate and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates compete with penicillins for renal tubular secretion and for plasma protein binding, which can modestly raise and prolong oxacillin levels. Trisalicylate is given at anti-inflammatory doses, so the effect may be more noticeable than with low-dose aspirin, particularly in renal impairment.
How serious is the interaction between Choline magnesium trisalicylate and Oxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed at usual doses. Monitor for oxacillin adverse effects in patients with renal impairment or receiving high doses.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Cholera vaccine. The full list is on the Oxacillin page.
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