Drug interactions
Choline magnesium trisalicylate + Paroxetine
Severity: Moderate
Choline magnesium trisalicylate and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates and SSRIs both impair hemostasis, raising the risk of bleeding, particularly in the upper gastrointestinal tract. Non-acetylated salicylates have less platelet effect than aspirin but still add GI risk.
What this interaction means in plain words
Choline magnesium trisalicylate and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRI platelet serotonin depletion combined with salicylate effects on mucosa and platelets.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Paroxetine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates and SSRIs both impair hemostasis, raising the risk of bleeding, particularly in the upper gastrointestinal tract. Non-acetylated salicylates have less platelet effect than aspirin but still add GI risk.
How serious is the interaction between Choline magnesium trisalicylate and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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