Drug interactions
Choline magnesium trisalicylate + Sacubitril-valsartan
Severity: Moderate
Choline magnesium trisalicylate and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have less prostaglandin effect than NSAIDs, but at high doses may still reduce valsartan's effect and affect renal function. Risk is greater in older or volume-depleted patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis may lower renal perfusion and blunt angiotensin receptor blocker effects.
What to do
Monitor renal function, potassium and blood pressure, and keep the salicylate dose as low as possible. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have less prostaglandin effect than NSAIDs, but at high doses may still reduce valsartan's effect and affect renal function. Risk is greater in older or volume-depleted patients.
How serious is the interaction between Choline magnesium trisalicylate and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and blood pressure, and keep the salicylate dose as low as possible. Ensure adequate hydration.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
