Drug interactions
Choline magnesium trisalicylate + Spironolactone
Severity: Moderate
Choline magnesium trisalicylate and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses may reduce the natriuretic effect of spironolactone and impair renal function, with a possible rise in potassium. Effects are generally modest but relevant in renal impairment or heart failure.
What this interaction means in plain words
Choline magnesium trisalicylate and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, and salicylates may reduce canrenone tubular secretion.
What to do
Monitor serum potassium, creatinine, blood pressure and fluid status; use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Spironolactone?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses may reduce the natriuretic effect of spironolactone and impair renal function, with a possible rise in potassium. Effects are generally modest but relevant in renal impairment or heart failure.
How serious is the interaction between Choline magnesium trisalicylate and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine, blood pressure and fluid status; use the lowest effective salicylate dose.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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