Drug interactions
Choline magnesium trisalicylate + Tobramycin
Severity: Moderate
Choline magnesium trisalicylate and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates reduce renal prostaglandin synthesis and may slow tobramycin elimination, best described in premature neonates. Salicylates also add some renal and ototoxic risk, so the combination deserves attention in vulnerable patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition reduces renal perfusion and glomerular filtration, lowering tobramycin clearance.
What to do
Monitor tobramycin troughs, serum creatinine and hearing in neonates, older adults or renal impairment. Use an alternative analgesic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Tobramycin?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates reduce renal prostaglandin synthesis and may slow tobramycin elimination, best described in premature neonates. Salicylates also add some renal and ototoxic risk, so the combination deserves attention in vulnerable patients.
How serious is the interaction between Choline magnesium trisalicylate and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin troughs, serum creatinine and hearing in neonates, older adults or renal impairment. Use an alternative analgesic when possible.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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