Drug interactions
Choline magnesium trisalicylate + Tolvaptan
Severity: Minor
Choline magnesium trisalicylate and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with a rise in serum potassium, although salicylate effects are small at usual doses. Risk is higher in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Choline magnesium trisalicylate and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effect on serum potassium; salicylates can reduce renal prostaglandin-mediated potassium excretion at higher doses.
What to do
Monitor serum potassium and renal function in at-risk patients. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Tolvaptan?
MediHelp rates the interaction as minor. Choline magnesium trisalicylate and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents have been associated with a rise in serum potassium, although salicylate effects are small at usual doses. Risk is higher in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Choline magnesium trisalicylate and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function in at-risk patients. No routine dose adjustment is needed.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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