Drug interactions
Choline magnesium trisalicylate + Trandolapril
Severity: Moderate
Choline magnesium trisalicylate and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates given with an ACE inhibitor can blunt the blood pressure lowering effect and may reduce renal function, particularly in older, volume-depleted or renally impaired patients. Choline magnesium trisalicylate has less prostaglandin inhibition than classic NSAIDs, so the effect is likely smaller.
What this interaction means in plain words
Choline magnesium trisalicylate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion and counteracts ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing the salicylate dose, and ensure adequate hydration. Use paracetamol as an alternative where appropriate in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Trandolapril?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates given with an ACE inhibitor can blunt the blood pressure lowering effect and may reduce renal function, particularly in older, volume-depleted or renally impaired patients. Choline magnesium trisalicylate has less prostaglandin inhibition than classic NSAIDs, so the effect is likely smaller.
How serious is the interaction between Choline magnesium trisalicylate and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing the salicylate dose, and ensure adequate hydration. Use paracetamol as an alternative where appropriate in high-risk patients.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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