Drug interactions
Choline magnesium trisalicylate + Valsartan
Severity: Moderate
Choline magnesium trisalicylate and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses this salicylate may reduce the antihypertensive effect of valsartan and impair renal function, though it has less prostaglandin inhibition than other NSAIDs. Risk is higher in elderly or volume-depleted patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ARB effects.
What to do
Monitor blood pressure, creatinine and potassium during regular use. Maintain hydration and use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Valsartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses this salicylate may reduce the antihypertensive effect of valsartan and impair renal function, though it has less prostaglandin inhibition than other NSAIDs. Risk is higher in elderly or volume-depleted patients.
How serious is the interaction between Choline magnesium trisalicylate and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium during regular use. Maintain hydration and use the lowest effective dose.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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