Drug interactions
Ciclesonide inhaled + Ketoconazole
Severity: Moderate
Ciclesonide inhaled and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises exposure to des-ciclesonide, the active metabolite of ciclesonide. Systemic corticosteroid effects such as adrenal suppression and Cushingoid features may occur, particularly with prolonged use.
What this interaction means in plain words
Ciclesonide inhaled and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition by ketoconazole reduces the metabolic clearance of ciclesonide and its active metabolite.
What to do
Monitor for signs of systemic corticosteroid excess during combined use, and consider an alternative antifungal if therapy is prolonged. Use the lowest effective ciclesonide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ciclesonide inhaled with Ketoconazole?
MediHelp rates the interaction as moderate. Ciclesonide inhaled and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole raises exposure to des-ciclesonide, the active metabolite of ciclesonide. Systemic corticosteroid effects such as adrenal suppression and Cushingoid features may occur, particularly with prolonged use.
How serious is the interaction between Ciclesonide inhaled and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during combined use, and consider an alternative antifungal if therapy is prolonged. Use the lowest effective ciclesonide dose.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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