Drug interactions
Cigarette smoking + Ropinirole
Severity: Moderate
Cigarette smoking and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces CYP1A2, which metabolizes ropinirole, so smokers have lower ropinirole exposure. Stopping smoking can raise levels and increase adverse effects.
What this interaction means in plain words
Cigarette smoking and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polycyclic hydrocarbons in smoke induce CYP1A2, increasing ropinirole clearance.
What to do
Adjust the ropinirole dose to clinical response when patients start or stop smoking. Watch for nausea, dizziness and somnolence after cessation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Cigarette smoking with Ropinirole?
MediHelp rates the interaction as moderate. Cigarette smoking and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Smoking induces CYP1A2, which metabolizes ropinirole, so smokers have lower ropinirole exposure. Stopping smoking can raise levels and increase adverse effects.
How serious is the interaction between Cigarette smoking and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the ropinirole dose to clinical response when patients start or stop smoking. Watch for nausea, dizziness and somnolence after cessation.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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