Drug interactions
Ciprofibrate + Glipizide-metformin
Severity: Moderate
Ciprofibrate and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been described. Fibrates can also improve insulin sensitivity, adding to the risk in patients on combined antidiabetic therapy.
What this interaction means in plain words
Ciprofibrate and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive glucose-lowering effect and displacement of glipizide from plasma proteins, though the clinical importance of protein binding displacement is uncertain.
What to do
Monitor blood glucose when starting or stopping ciprofibrate and reduce the glipizide dose if hypoglycemia occurs. Pay particular attention in patients with low albumin or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Ciprofibrate with Glipizide-metformin?
MediHelp rates the interaction as moderate. Ciprofibrate and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been described. Fibrates can also improve insulin sensitivity, adding to the risk in patients on combined antidiabetic therapy.
How serious is the interaction between Ciprofibrate and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ciprofibrate and reduce the glipizide dose if hypoglycemia occurs. Pay particular attention in patients with low albumin or renal impairment.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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