Drug interactions
Ciprofibrate + Insulin glargine-lixisenatide
Severity: Moderate
Ciprofibrate and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates can improve insulin sensitivity and may enhance the glucose-lowering effect of insulin. Hypoglycemia has been reported, particularly with low albumin levels.
What this interaction means in plain words
Ciprofibrate and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fibrates activate PPAR-alpha and may improve insulin sensitivity, giving an additive pharmacodynamic effect.
What to do
Monitor blood glucose when starting ciprofibrate and reduce the insulin dose if hypoglycemia occurs. Take extra care in patients with hypoalbuminemia or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Ciprofibrate with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Ciprofibrate and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates can improve insulin sensitivity and may enhance the glucose-lowering effect of insulin. Hypoglycemia has been reported, particularly with low albumin levels.
How serious is the interaction between Ciprofibrate and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting ciprofibrate and reduce the insulin dose if hypoglycemia occurs. Take extra care in patients with hypoalbuminemia or renal impairment.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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