Drug interactions
Citalopram + Dipyridamole
Severity: Moderate
Citalopram and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram depletes platelet serotonin and can increase bleeding tendency. Combined with dipyridamole, an antiplatelet agent, bleeding risk may be modestly increased.
What this interaction means in plain words
Citalopram and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Dipyridamole belongs to Cardiovascular.
Why it happens
Additive impairment of platelet function (SSRI serotonin depletion plus dipyridamole's adenosine-mediated platelet inhibition).
What to do
Monitor for bruising and GI or other bleeding. Consider gastroprotection in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Dipyridamole?
MediHelp rates the interaction as moderate. Citalopram and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram depletes platelet serotonin and can increase bleeding tendency. Combined with dipyridamole, an antiplatelet agent, bleeding risk may be modestly increased.
How serious is the interaction between Citalopram and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and GI or other bleeding. Consider gastroprotection in patients at high GI risk.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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