Drug interactions
Citalopram + Eprosartan-hydrochlorothiazide
Severity: Moderate
Citalopram and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and SSRIs such as citalopram can cause hyponatremia, and the risk is additive. Older adults and women are most at risk, and severe cases present with confusion, falls or seizures. Thiazide-induced hypokalemia or hypomagnesemia can also add to citalopram QT risk.
What this interaction means in plain words
Citalopram and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive effects on sodium handling: thiazide-induced renal sodium loss combined with SSRI-associated SIADH.
What to do
Check serum sodium at baseline and within the first few weeks of combined therapy, and monitor potassium and magnesium. Stop or change one drug if symptomatic or significant hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Citalopram and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and SSRIs such as citalopram can cause hyponatremia, and the risk is additive. Older adults and women are most at risk, and severe cases present with confusion, falls or seizures. Thiazide-induced hypokalemia or hypomagnesemia can also add to citalopram QT risk.
How serious is the interaction between Citalopram and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and within the first few weeks of combined therapy, and monitor potassium and magnesium. Stop or change one drug if symptomatic or significant hyponatremia develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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