Drug interactions
Citalopram + Eptifibatide
Severity: Moderate
Citalopram and Eptifibatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram reduces platelet serotonin content and can increase the risk of bruising and gastrointestinal bleeding. With eptifibatide, the bleeding risk may be further increased.
What this interaction means in plain words
Citalopram and Eptifibatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Eptifibatide belongs to Cardiovascular.
Why it happens
Additive impairment of platelet aggregation: SSRI-mediated depletion of platelet serotonin plus GP IIb/IIIa inhibition.
What to do
Monitor for bleeding and hemoglobin during eptifibatide infusion. Consider gastroprotection in patients with additional GI bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eptifibatide
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Eptifibatide?
MediHelp rates the interaction as moderate. Citalopram and Eptifibatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram reduces platelet serotonin content and can increase the risk of bruising and gastrointestinal bleeding. With eptifibatide, the bleeding risk may be further increased.
How serious is the interaction between Citalopram and Eptifibatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin during eptifibatide infusion. Consider gastroprotection in patients with additional GI bleeding risk factors.
What other medicines interact with Eptifibatide?
MediHelp also lists interactions of Eptifibatide with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Eptifibatide page.
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