Drug interactions
Citalopram + Ezogabine
Severity: Moderate
Citalopram and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can cause slight QT prolongation, and citalopram has a dose-related QT effect, so combined use may increase arrhythmia risk. The risk is greater at higher doses and with electrolyte abnormalities.
What this interaction means in plain words
Citalopram and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Monitor the ECG and correct potassium and magnesium abnormalities, particularly during ezogabine titration. Avoid higher citalopram doses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Citalopram with Ezogabine?
MediHelp rates the interaction as moderate. Citalopram and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can cause slight QT prolongation, and citalopram has a dose-related QT effect, so combined use may increase arrhythmia risk. The risk is greater at higher doses and with electrolyte abnormalities.
How serious is the interaction between Citalopram and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and correct potassium and magnesium abnormalities, particularly during ezogabine titration. Avoid higher citalopram doses where possible.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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