Drug interactions
Citalopram + Ganaxolone
Severity: Moderate
Citalopram and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid that causes somnolence and sedation. Combined with citalopram, which can also cause drowsiness, central nervous system effects may be more pronounced.
What this interaction means in plain words
Citalopram and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic effects.
What to do
Monitor for excessive sedation and impaired psychomotor performance, and advise patients to avoid driving until the response is known. Reduce the ganaxolone dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Citalopram with Ganaxolone?
MediHelp rates the interaction as moderate. Citalopram and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid that causes somnolence and sedation. Combined with citalopram, which can also cause drowsiness, central nervous system effects may be more pronounced.
How serious is the interaction between Citalopram and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired psychomotor performance, and advise patients to avoid driving until the response is known. Reduce the ganaxolone dose if sedation is troublesome.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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