Drug interactions
Enzalutamide + Ganaxolone
Severity: Major
Enzalutamide and Ganaxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is cleared by CYP3A4, and enzalutamide may lower its exposure. Seizure control may worsen, and enzalutamide also lowers seizure threshold.
What this interaction means in plain words
Enzalutamide and Ganaxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Ganaxolone belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, increasing ganaxolone clearance.
What to do
Avoid combining. If unavoidable, consider raising ganaxolone dose within the weight-based maximum and monitor seizure frequency.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Ganaxolone
- Amobarbital + Ganaxolone Major
- Apalutamide + Ganaxolone Major
- Armodafinil + Ganaxolone Major
- Carbamazepine + Ganaxolone Major
- Ganaxolone + Phenytoin Major
- Ganaxolone + Rifampicin Major
Frequently asked questions
Can I take Enzalutamide with Ganaxolone?
MediHelp rates the interaction as major. Enzalutamide and Ganaxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ganaxolone is cleared by CYP3A4, and enzalutamide may lower its exposure. Seizure control may worsen, and enzalutamide also lowers seizure threshold.
How serious is the interaction between Enzalutamide and Ganaxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining. If unavoidable, consider raising ganaxolone dose within the weight-based maximum and monitor seizure frequency.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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