Drug interactions
Citalopram + Glyburide-metformin
Severity: Minor
Citalopram and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as citalopram have occasionally been linked to changes in glucose control, including hypoglycemia in patients on antidiabetic agents. The effect is inconsistent and usually modest, but it may be noticeable in patients taking a sulfonylurea.
What this interaction means in plain words
Citalopram and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effects through altered insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping citalopram and adjust the glyburide-metformin dose if glucose control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Glyburide-metformin?
MediHelp rates the interaction as minor. Citalopram and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as citalopram have occasionally been linked to changes in glucose control, including hypoglycemia in patients on antidiabetic agents. The effect is inconsistent and usually modest, but it may be noticeable in patients taking a sulfonylurea.
How serious is the interaction between Citalopram and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping citalopram and adjust the glyburide-metformin dose if glucose control changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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