Drug interactions
Citalopram + Ibrutinib
Severity: Moderate
Citalopram and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and raises bleeding risk, and SSRIs also reduce platelet aggregation. Together they may increase the chance of significant bleeding.
What this interaction means in plain words
Citalopram and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Ibrutinib belongs to Oncology.
Why it happens
Additive platelet dysfunction from BTK inhibition and SSRI-induced platelet serotonin depletion.
What to do
Monitor for bruising and bleeding and hold ibrutinib around surgery as labeled. Reassess the need for the SSRI in patients with other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Citalopram with Ibrutinib?
MediHelp rates the interaction as moderate. Citalopram and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and raises bleeding risk, and SSRIs also reduce platelet aggregation. Together they may increase the chance of significant bleeding.
How serious is the interaction between Citalopram and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding and hold ibrutinib around surgery as labeled. Reassess the need for the SSRI in patients with other bleeding risk factors.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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