Drug interactions
Citalopram + Istradefylline
Severity: Minor
Citalopram and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as citalopram. This can raise the risk of dose-related adverse effects.
What this interaction means in plain words
Citalopram and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline at 40 mg/day.
What to do
Monitor for increased citalopram adverse effects when istradefylline 40 mg/day is used. Reduce the citalopram dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Citalopram and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Citalopram with Istradefylline?
MediHelp rates the interaction as minor. Citalopram and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as citalopram. This can raise the risk of dose-related adverse effects.
How serious is the interaction between Citalopram and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased citalopram adverse effects when istradefylline 40 mg/day is used. Reduce the citalopram dose if adverse effects appear.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
