Drug interactions
Citalopram + Mavacamten
Severity: Moderate
Citalopram and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19, and citalopram is a weak inhibitor of that enzyme in some contexts, so mavacamten exposure may rise. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
What this interaction means in plain words
Citalopram and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Possible CYP2C19 inhibition reduces mavacamten clearance.
What to do
Monitor echocardiographic LVEF and clinical status when citalopram is started or stopped, and adjust mavacamten dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Citalopram with Mavacamten?
MediHelp rates the interaction as moderate. Citalopram and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized mainly by CYP2C19, and citalopram is a weak inhibitor of that enzyme in some contexts, so mavacamten exposure may rise. Excess exposure can reduce left ventricular ejection fraction and cause heart failure.
How serious is the interaction between Citalopram and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor echocardiographic LVEF and clinical status when citalopram is started or stopped, and adjust mavacamten dose per labeling.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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