Drug interactions
Citalopram + Pazopanib
Severity: Major
Citalopram and Pazopanib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and cause torsades de pointes, and citalopram has a similar dose-related effect. Combining them increases arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Citalopram and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform a baseline ECG and monitor ECG and electrolytes during therapy. Choose an alternative antidepressant if the QTc rises markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Citalopram with Pazopanib?
MediHelp rates the interaction as major. Citalopram and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib can prolong the QT interval and cause torsades de pointes, and citalopram has a similar dose-related effect. Combining them increases arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Citalopram and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor ECG and electrolytes during therapy. Choose an alternative antidepressant if the QTc rises markedly.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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