Drug interactions
Citalopram + Selpercatinib
Severity: Major
Citalopram and Selpercatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and citalopram has a dose-dependent QT effect. Together they may increase the risk of torsades de pointes.
What this interaction means in plain words
Citalopram and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain baseline and periodic ECGs and correct potassium and magnesium. Consider a lower citalopram dose or alternative antidepressant if the QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Citalopram with Selpercatinib?
MediHelp rates the interaction as major. Citalopram and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can prolong the QT interval, and citalopram has a dose-dependent QT effect. Together they may increase the risk of torsades de pointes.
How serious is the interaction between Citalopram and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct potassium and magnesium. Consider a lower citalopram dose or alternative antidepressant if the QTc rises.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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