Drug interactions
Citalopram + Sorafenib
Severity: Major
Citalopram and Sorafenib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, adding to the QT effect of citalopram. The combination raises the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Citalopram and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes periodically. Correct hypokalemia and hypomagnesemia, and consider an alternative antidepressant if the QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Citalopram with Sorafenib?
MediHelp rates the interaction as major. Citalopram and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sorafenib can prolong the QT interval, adding to the QT effect of citalopram. The combination raises the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Citalopram and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes periodically. Correct hypokalemia and hypomagnesemia, and consider an alternative antidepressant if the QTc rises.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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