Drug interactions
Citalopram + Triptorelin
Severity: Moderate
Citalopram and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with triptorelin can prolong the QT interval, and citalopram also affects repolarization. Together they may increase the risk of torsades de pointes, particularly in older men with cardiac disease.
What this interaction means in plain words
Citalopram and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with androgen deprivation altering cardiac repolarization.
What to do
Obtain a baseline ECG and electrolytes and repeat them periodically. Consider an antidepressant with less QT effect if other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Citalopram with Triptorelin?
MediHelp rates the interaction as moderate. Citalopram and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with triptorelin can prolong the QT interval, and citalopram also affects repolarization. Together they may increase the risk of torsades de pointes, particularly in older men with cardiac disease.
How serious is the interaction between Citalopram and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat them periodically. Consider an antidepressant with less QT effect if other risk factors are present.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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