Drug interactions
Citric acid / glucono-delta-lactone / magnesium carbonate + Deferiprone
Severity: Moderate
Citric acid / glucono-delta-lactone / magnesium carbonate and Deferiprone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone binds polyvalent cations such as magnesium in the gut. This magnesium-containing preparation may reduce deferiprone absorption and its iron-chelating effect.
What this interaction means in plain words
Citric acid / glucono-delta-lactone / magnesium carbonate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of deferiprone by magnesium ions in the gastrointestinal lumen reduces absorption.
What to do
Separate doses by at least 4 hours. Monitor serum ferritin for loss of chelation efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Citric acid / glucono-delta-lactone / magnesium carbonate with Deferiprone?
MediHelp rates the interaction as moderate. Citric acid / glucono-delta-lactone / magnesium carbonate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone binds polyvalent cations such as magnesium in the gut. This magnesium-containing preparation may reduce deferiprone absorption and its iron-chelating effect.
How serious is the interaction between Citric acid / glucono-delta-lactone / magnesium carbonate and Deferiprone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 4 hours. Monitor serum ferritin for loss of chelation efficacy.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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