Drug interactions
Citric acid / sodium bicarbonate + Ledipasvir-sofosbuvir
Severity: Moderate
Citric acid / sodium bicarbonate and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This buffering agent raises gastric pH, and ledipasvir dissolves poorly at higher pH, so absorption may fall. Reduced exposure could compromise hepatitis C treatment response.
What this interaction means in plain words
Citric acid / sodium bicarbonate and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH reduces the solubility and absorption of ledipasvir.
What to do
Separate antacid and ledipasvir/sofosbuvir doses by 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Frequently asked questions
Can I take Citric acid / sodium bicarbonate with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Citric acid / sodium bicarbonate and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This buffering agent raises gastric pH, and ledipasvir dissolves poorly at higher pH, so absorption may fall. Reduced exposure could compromise hepatitis C treatment response.
How serious is the interaction between Citric acid / sodium bicarbonate and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate antacid and ledipasvir/sofosbuvir doses by 4 hours.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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