Drug interactions
Citric acid / sodium bicarbonate + Nilotinib
Severity: Moderate
Citric acid / sodium bicarbonate and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The alkalinizing agents raise gastric pH, which can lower nilotinib dissolution and absorption.
What this interaction means in plain words
Citric acid / sodium bicarbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces nilotinib absorption.
What to do
Take the antacid at least 2 hours before or after nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Citric acid / sodium bicarbonate with Nilotinib?
MediHelp rates the interaction as moderate. Citric acid / sodium bicarbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The alkalinizing agents raise gastric pH, which can lower nilotinib dissolution and absorption.
How serious is the interaction between Citric acid / sodium bicarbonate and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the antacid at least 2 hours before or after nilotinib.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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