Drug interactions
Citric acid / sodium bicarbonate + Pazopanib
Severity: Moderate
Citric acid / sodium bicarbonate and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on gastric acidity, and agents that raise gastric pH reduce its exposure. An oral citric acid and sodium bicarbonate preparation is a short-acting antacid and may lower pazopanib absorption, with a risk of reduced antitumor effect.
What this interaction means in plain words
Citric acid / sodium bicarbonate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH decreases the solubility and absorption of pazopanib.
What to do
If an antacid is needed, give it at least 2 hours after or 1 hour before pazopanib, and avoid long-acting acid suppressants. Pazopanib should be taken without food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Citric acid / sodium bicarbonate with Pazopanib?
MediHelp rates the interaction as moderate. Citric acid / sodium bicarbonate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on gastric acidity, and agents that raise gastric pH reduce its exposure. An oral citric acid and sodium bicarbonate preparation is a short-acting antacid and may lower pazopanib absorption, with a risk of reduced antitumor effect.
How serious is the interaction between Citric acid / sodium bicarbonate and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours after or 1 hour before pazopanib, and avoid long-acting acid suppressants. Pazopanib should be taken without food.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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