Drug interactions
Cladribine + Palifermin
Severity: Moderate
Cladribine and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates growth of epithelial cells, which may make them more vulnerable to cytotoxic chemotherapy if given close in time. Labeling for palifermin reports worse and longer oral mucositis when it was given within 24 hours of chemotherapy.
What this interaction means in plain words
Cladribine and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-stimulated epithelial proliferation increases sensitivity of mucosal cells to cytotoxic agents.
What to do
Do not give palifermin within 24 hours before, during, or 24 hours after cladribine. Follow the labeled timing and monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Other interactions of Palifermin
Frequently asked questions
Can I take Cladribine with Palifermin?
MediHelp rates the interaction as moderate. Cladribine and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates growth of epithelial cells, which may make them more vulnerable to cytotoxic chemotherapy if given close in time. Labeling for palifermin reports worse and longer oral mucositis when it was given within 24 hours of chemotherapy.
How serious is the interaction between Cladribine and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or 24 hours after cladribine. Follow the labeled timing and monitor for mucositis.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
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