Drug interactions
Dacarbazine + Palifermin
Severity: Major
Dacarbazine and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, the severity and duration of oral mucositis increased.
What this interaction means in plain words
Dacarbazine and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacarbazine belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced keratinocyte proliferation may sensitize mucosal epithelium to cytotoxic agents.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after dacarbazine. Follow the labeled schedule around chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dacarbazine
Other interactions of Palifermin
Frequently asked questions
Can I take Dacarbazine with Palifermin?
MediHelp rates the interaction as major. Dacarbazine and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, the severity and duration of oral mucositis increased.
How serious is the interaction between Dacarbazine and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after dacarbazine. Follow the labeled schedule around chemotherapy.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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