Drug interactions
Clemastine + Diphenoxylate-atropine
Severity: Moderate
Clemastine and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating, anticholinergic first-generation antihistamine. Combined with diphenoxylate-atropine it may increase drowsiness and antimuscarinic effects such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Clemastine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive antimuscarinic effects.
What to do
Advise about sedation and anticholinergic symptoms; use a non-sedating antihistamine if possible and monitor older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Clemastine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating, anticholinergic first-generation antihistamine. Combined with diphenoxylate-atropine it may increase drowsiness and antimuscarinic effects such as dry mouth, constipation and urinary retention.
How serious is the interaction between Clemastine and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise about sedation and anticholinergic symptoms; use a non-sedating antihistamine if possible and monitor older adults.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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