Drug interactions
Clemastine + Dosulepin
Severity: Moderate
Clemastine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic properties, and clemastine adds to these effects. The combination can cause excessive sedation, dry mouth, constipation, blurred vision, urinary retention and cognitive impairment.
What this interaction means in plain words
Clemastine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive H1-antihistaminic and antimuscarinic effects in the CNS and periphery.
What to do
Prefer a non-sedating antihistamine in patients taking dosulepin. If the combination is needed, monitor for anticholinergic toxicity and oversedation, particularly in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clemastine and Dosulepin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clemastine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Clemastine with Dosulepin?
MediHelp rates the interaction as moderate. Clemastine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic properties, and clemastine adds to these effects. The combination can cause excessive sedation, dry mouth, constipation, blurred vision, urinary retention and cognitive impairment.
How serious is the interaction between Clemastine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine in patients taking dosulepin. If the combination is needed, monitor for anticholinergic toxicity and oversedation, particularly in the elderly.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
