Drug interactions
Clemastine + Pitolisant
Severity: Moderate
Clemastine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant enhances wakefulness by increasing brain histamine release, and centrally acting H1 antagonists such as clemastine can block this effect. Pitolisant efficacy may be reduced.
What this interaction means in plain words
Clemastine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Pitolisant belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: central H1 blockade opposes histamine-mediated wake promotion by pitolisant.
What to do
Avoid clemastine and use a non-sedating antihistamine. Monitor for loss of wakefulness benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Clemastine with Pitolisant?
MediHelp rates the interaction as moderate. Clemastine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant enhances wakefulness by increasing brain histamine release, and centrally acting H1 antagonists such as clemastine can block this effect. Pitolisant efficacy may be reduced.
How serious is the interaction between Clemastine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid clemastine and use a non-sedating antihistamine. Monitor for loss of wakefulness benefit.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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