Drug interactions
Clemastine + Zuranolone
Severity: Moderate
Clemastine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving, and clemastine increases these effects. The combination may worsen CNS depression and psychomotor impairment.
What this interaction means in plain words
Clemastine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation plus H1 antagonism.
What to do
Prefer a non-sedating antihistamine. If both are used, consider reducing the zuranolone dose and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Clemastine with Zuranolone?
MediHelp rates the interaction as moderate. Clemastine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving, and clemastine increases these effects. The combination may worsen CNS depression and psychomotor impairment.
How serious is the interaction between Clemastine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If both are used, consider reducing the zuranolone dose and advise against driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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