Drug interactions
Clindamycin + Mipomersen
Severity: Moderate
Clindamycin and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen is associated with hepatotoxicity and raised transaminases, and clindamycin can also occasionally raise liver enzymes. Using both may add to liver injury risk, although the interaction is largely theoretical.
What this interaction means in plain words
Clindamycin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin during coadministration, and follow mipomersen label thresholds for interrupting therapy if enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clindamycin
Frequently asked questions
Can I take Clindamycin with Mipomersen?
MediHelp rates the interaction as moderate. Clindamycin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen is associated with hepatotoxicity and raised transaminases, and clindamycin can also occasionally raise liver enzymes. Using both may add to liver injury risk, although the interaction is largely theoretical.
How serious is the interaction between Clindamycin and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin during coadministration, and follow mipomersen label thresholds for interrupting therapy if enzymes rise.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
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