Drug interactions
Clonazepam + Clonidine
Severity: Moderate
Clonazepam and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine and clonazepam both cause sedation, and clonidine adds blood pressure lowering. Combined use can produce excessive drowsiness, impaired coordination and hypotension.
What this interaction means in plain words
Clonazepam and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Clonidine belongs to Cardiovascular.
Why it happens
Additive CNS depression via central alpha-2 agonism and GABA-A potentiation.
What to do
Use the lowest effective doses and monitor sedation and blood pressure, particularly in older patients. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Clonidine?
MediHelp rates the interaction as moderate. Clonazepam and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine and clonazepam both cause sedation, and clonidine adds blood pressure lowering. Combined use can produce excessive drowsiness, impaired coordination and hypotension.
How serious is the interaction between Clonazepam and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure, particularly in older patients. Avoid alcohol and other sedatives.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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