Drug interactions
Clonazepam + Conivaptan
Severity: Moderate
Clonazepam and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and may raise clonazepam concentrations, intensifying sedation and psychomotor impairment. The effect is likely modest because clonazepam clearance is only partly CYP3A4 dependent, and conivaptan is used short term.
What this interaction means in plain words
Clonazepam and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing clonazepam metabolism.
What to do
Monitor for excess sedation and respiratory depression during conivaptan infusion. Reduce the clonazepam dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Conivaptan?
MediHelp rates the interaction as moderate. Clonazepam and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan inhibits CYP3A4 and may raise clonazepam concentrations, intensifying sedation and psychomotor impairment. The effect is likely modest because clonazepam clearance is only partly CYP3A4 dependent, and conivaptan is used short term.
How serious is the interaction between Clonazepam and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression during conivaptan infusion. Reduce the clonazepam dose if oversedation occurs.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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