Drug interactions
Clonazepam + Dabrafenib
Severity: Moderate
Clonazepam and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce clonazepam concentrations, which can weaken seizure or anxiety control.
What this interaction means in plain words
Clonazepam and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by dabrafenib accelerates clonazepam metabolism.
What to do
Monitor clinical response to clonazepam, especially seizure control, and adjust dose as needed. Reassess when dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Clonazepam with Dabrafenib?
MediHelp rates the interaction as moderate. Clonazepam and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may reduce clonazepam concentrations, which can weaken seizure or anxiety control.
How serious is the interaction between Clonazepam and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to clonazepam, especially seizure control, and adjust dose as needed. Reassess when dabrafenib is discontinued.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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