Drug interactions
Clonazepam + Danazol
Severity: Moderate
Clonazepam and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may increase clonazepam levels, leading to greater sedation and psychomotor impairment. The effect is predicted from mechanism rather than well quantified.
What this interaction means in plain words
Clonazepam and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of clonazepam.
What to do
Monitor for increased drowsiness and ataxia and reduce the clonazepam dose if these occur. Reassess when danazol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Danazol?
MediHelp rates the interaction as moderate. Clonazepam and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase clonazepam levels, leading to greater sedation and psychomotor impairment. The effect is predicted from mechanism rather than well quantified.
How serious is the interaction between Clonazepam and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and ataxia and reduce the clonazepam dose if these occur. Reassess when danazol is stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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