Drug interactions
Clonazepam + Diazepam intranasal
Severity: Moderate
Clonazepam and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression. Intranasal diazepam for seizure rescue may produce excessive sedation in a patient already taking clonazepam.
What this interaction means in plain words
Clonazepam and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation causing CNS depression.
What to do
Monitor for oversedation and respiratory depression after a rescue dose, especially if repeated. Avoid routine duplicate benzodiazepine therapy beyond planned seizure-rescue use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Diazepam intranasal?
MediHelp rates the interaction as moderate. Clonazepam and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression. Intranasal diazepam for seizure rescue may produce excessive sedation in a patient already taking clonazepam.
How serious is the interaction between Clonazepam and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory depression after a rescue dose, especially if repeated. Avoid routine duplicate benzodiazepine therapy beyond planned seizure-rescue use.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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