Drug interactions
Clonazepam + Disulfiram
Severity: Moderate
Clonazepam and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram can reduce the clearance of some benzodiazepines and raise their levels, leading to more sedation and psychomotor impairment. The effect is best documented for oxidatively metabolized benzodiazepines such as diazepam and chlordiazepoxide, and clonazepam may be affected similarly.
What this interaction means in plain words
Clonazepam and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Disulfiram inhibits hepatic oxidative (CYP-mediated) metabolism of benzodiazepines.
What to do
Monitor for excess sedation and reduce the clonazepam dose if needed when starting disulfiram.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clonazepam and Disulfiram, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Disulfiram?
MediHelp rates the interaction as moderate. Clonazepam and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram can reduce the clearance of some benzodiazepines and raise their levels, leading to more sedation and psychomotor impairment. The effect is best documented for oxidatively metabolized benzodiazepines such as diazepam and chlordiazepoxide, and clonazepam may be affected similarly.
How serious is the interaction between Clonazepam and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the clonazepam dose if needed when starting disulfiram.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
