Drug interactions
Clonazepam + Esketamine
Severity: Moderate
Clonazepam and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Concurrent use can deepen sedation and impair cognition and coordination, with possible respiratory depression in vulnerable patients.
What this interaction means in plain words
Clonazepam and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression via NMDA receptor antagonism and GABA-A potentiation.
What to do
Monitor sedation and respiratory status, and extend post-dose observation if needed. Use the lowest effective benzodiazepine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Esketamine?
MediHelp rates the interaction as moderate. Clonazepam and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system. Concurrent use can deepen sedation and impair cognition and coordination, with possible respiratory depression in vulnerable patients.
How serious is the interaction between Clonazepam and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and extend post-dose observation if needed. Use the lowest effective benzodiazepine dose.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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