Drug interactions
Clonazepam + Fexinidazole
Severity: Moderate
Clonazepam and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise clonazepam concentrations, increasing sedation and impairment. Fexinidazole is given for a short course in a supervised setting.
What this interaction means in plain words
Clonazepam and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing clonazepam metabolism.
What to do
Monitor for oversedation and reduce the clonazepam dose if needed during fexinidazole therapy. Consider an alternative anticonvulsant or anxiolytic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Fexinidazole?
MediHelp rates the interaction as moderate. Clonazepam and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise clonazepam concentrations, increasing sedation and impairment. Fexinidazole is given for a short course in a supervised setting.
How serious is the interaction between Clonazepam and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the clonazepam dose if needed during fexinidazole therapy. Consider an alternative anticonvulsant or anxiolytic if feasible.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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