Drug interactions
Clonazepam + Flurazepam
Severity: Moderate
Clonazepam and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two benzodiazepines together adds sedation, impaired coordination and respiratory depression. Flurazepam has long-acting active metabolites, which increases the risk of next-day impairment and falls.
What this interaction means in plain words
Clonazepam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid concurrent use of two benzodiazepines; if unavoidable, use the lowest doses and monitor sedation and psychomotor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Flurazepam?
MediHelp rates the interaction as moderate. Clonazepam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two benzodiazepines together adds sedation, impaired coordination and respiratory depression. Flurazepam has long-acting active metabolites, which increases the risk of next-day impairment and falls.
How serious is the interaction between Clonazepam and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines; if unavoidable, use the lowest doses and monitor sedation and psychomotor function.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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