Drug interactions
Clonazepam + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Clonazepam and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptive estrogens may reduce the clearance of some benzodiazepines. Clonazepam is mainly nitroreduced and acetylated rather than oxidised, so any effect is likely small.
What this interaction means in plain words
Clonazepam and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of oxidative hepatic metabolism of benzodiazepines by ethinylestradiol.
What to do
No routine adjustment is needed; watch for increased drowsiness after starting the contraceptive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Clonazepam and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptive estrogens may reduce the clearance of some benzodiazepines. Clonazepam is mainly nitroreduced and acetylated rather than oxidised, so any effect is likely small.
How serious is the interaction between Clonazepam and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased drowsiness after starting the contraceptive.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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