Drug interactions
Clonazepam + Olanzapine / samidorphan
Severity: Moderate
Clonazepam and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonazepam and olanzapine produce additive sedation and can worsen orthostatic hypotension when combined. This raises the risk of dizziness, falls and impaired psychomotor performance, particularly in older or frail patients.
What this interaction means in plain words
Clonazepam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and alpha-adrenergic related hypotensive effects (pharmacodynamic synergism).
What to do
Start with the lowest effective doses and monitor sedation and standing blood pressure, especially during initiation or dose increases. Counsel patients to avoid alcohol and to rise slowly from sitting or lying.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Clonazepam with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Clonazepam and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonazepam and olanzapine produce additive sedation and can worsen orthostatic hypotension when combined. This raises the risk of dizziness, falls and impaired psychomotor performance, particularly in older or frail patients.
How serious is the interaction between Clonazepam and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor sedation and standing blood pressure, especially during initiation or dose increases. Counsel patients to avoid alcohol and to rise slowly from sitting or lying.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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