Drug interactions
Clonazepam + Pimozide
Severity: Moderate
Clonazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so combined use may increase drowsiness and impair psychomotor performance. Pimozide additionally carries QT prolongation risk, although clonazepam does not meaningfully add to this.
What this interaction means in plain words
Clonazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and pimozide central dopamine blockade.
What to do
Monitor for excessive sedation and counsel patients on driving and alcohol. Continue routine ECG and electrolyte monitoring for pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Clonazepam with Pimozide?
MediHelp rates the interaction as moderate. Clonazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so combined use may increase drowsiness and impair psychomotor performance. Pimozide additionally carries QT prolongation risk, although clonazepam does not meaningfully add to this.
How serious is the interaction between Clonazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients on driving and alcohol. Continue routine ECG and electrolyte monitoring for pimozide.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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