Drug interactions
Clonazepam + Remimazolam
Severity: Major
Clonazepam and Remimazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is an ultra-short-acting benzodiazepine, and with clonazepam it may produce deeper or more prolonged sedation, with respiratory depression, hypoxia and hypotension.
What this interaction means in plain words
Clonazepam and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonazepam belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS and respiratory depression.
What to do
Titrate remimazolam carefully with a reduced dose in patients on clonazepam. Continuously monitor oxygenation and vital signs through recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Remimazolam
Frequently asked questions
Can I take Clonazepam with Remimazolam?
MediHelp rates the interaction as major. Clonazepam and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is an ultra-short-acting benzodiazepine, and with clonazepam it may produce deeper or more prolonged sedation, with respiratory depression, hypoxia and hypotension.
How serious is the interaction between Clonazepam and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully with a reduced dose in patients on clonazepam. Continuously monitor oxygenation and vital signs through recovery.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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